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"Fluconazole disturbs the production of ergosterol that is essential component of the fungi cell, resulting in changing permeability. It is important to take the Diflucan medication at evenly spaced intervals. Fluconazole works best if it is taken at the same time each day. If you experience any of the serious side effects, stop taking Diflucan without talking to your doctor if you have liver disease, kidney disease, or a heart rhythm disorder."