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Bill Hales noticed: "Hydrochlorothiazide has an additive effect on lowering blood pressure. Hydrochlorothiazide increases the removal of salts from the blood, it also causes more water to be drawn out of the blood and into the urine. Hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects. Although there are no adequate and well-controlled studies using hydrochlorothiazide in pregnancy, thiazide diuretics may cause an increased risk of congenital defects. Hydrochlorothiazide belongs to the thiazide class of diuretics, acting on the kidney to reduce sodium reabsorption in the distal convoluted tubule. The dose of your antidiabetic medicine may need adjusting. As heart, liver, or kidney disease."