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Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celebrex works by blocking the action of a substance in the body called cyclo-oxygenase. Celecoxib is used to reduce pain and inflammation in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, the dose usually is 100 mg twice daily or 200 mg as a single dose. Fluconazole increases the concentration of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the body called cyclo-oxygenase. Before taking Celecoxib, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. Before using this medication, tell your doctor or pharmacist your medical history, especially of blood flow problem in the brain. If you are allergic to it or to sulfa drugs. Celecoxib should only be used in pregnant women when the benefits outweigh the potential risk to the fetus.