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This medicine suddenly, particularly if you have ischemic heart disease. Inderal reduces the energy used by the heart to pump blood around the body, and so reduces the heart's need for oxygen, which means it can also be used in the management of angina. In the judgment of the physician, treatment should be started with a beta-blocker rather than a diuretic. Propranolol from Inderal tablets is rapidly and completely absorbed from the gastrointestinal tract and undergoes extensive presystemic elimination due to its high hepatic clearance. If Propranolol is taken in combination with clonidine to lower blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. In which Propranolol was used as a suicide agent. Propranolol from Inderal tablets is rapidly and completely absorbed from the gastrointestinal tract. There may be an increased risk of slow heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction. Care should be taken if adrenaline is given with Propranolol, as this combination can cause severely high blood pressure and heart failure.