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Possible deleterious effects from long-term use of Propranolol have not yet been adequately appraised. If Propranolol is taken in combination with clonidine to lower blood pressure, there is a risk of a rebound increase in blood pressure if the clonidine is stopped. Treatment must always be initiated and individual titration of dosage carried out using the conventional tablets. If adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals. There may be an increased risk of slow heart rate, tremor and nausea.
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