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Esomeprazole reduce the production of acid in the stomach. If taken on an empty stomach at least one hour before a meal. The wall of the stomach that produces acid. Esomeprazole works best if taken on an empty stomach at least one hour before a meal. Use this medication. If taken on an empty stomach at least one hour before a meal. Esomeprazole reduce the production of acid in the stomach, Nexium reduces the amount of acid produced in the stomach, Nexium reduces the amount of acid produced in the stomach and intestines by blocking the enzyme in the wall of the stomach that produces acid.

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