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When to take glucophage doses: "Glucophage tablets are standard release tablets that are taken two or three times a day either during or just after meals. Metformin increases the sensitivity of muscle cells to insulin. Metformin delays absorption of sugar from the intestines into the bloodstream after eating. If the patient is taking Glucophage tablets, the starting dose is 500 mg daily with the evening meal. Metformin also increases your body's response to insulin, Metformin may decrease the risk of lactic acidosis while you are taking this medicine. Metformin works by helping to restore your body's response to insulin, a natural substance that controls the amount of glucose made by your liver. Metformin also increases your body's proper response to the insulin you naturally produce, and by decreasing the amount of glucose you absorb from your food and the amount of sugar produced by cells in the liver. Overall, Metformin reduces blood sugar levels can rise too high."